Controlled protein release from monodisperse biodegradable double-wall microspheres of controllable shell thickness
نویسندگان
چکیده
منابع مشابه
Controlled-release and preserved bioactivity of proteins from (self-assembled) core-shell double-walled microspheres
In order to address preserved protein bioactivities and protein sustained-release problems, a method for preparing double-walled microspheres with a core (protein-loaded nanoparticles with a polymer-suspended granule system-formed core) and a second shell (a polymer-formed shell) for controlled drug release and preserved protein bioactivities has been developed using (solid-in-oil phase-in-hydr...
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Biodegradable microspheres are effective devices for controlled drug release, and it is desireable to be able to monitor their distribution in vivo in order to optimize delivery methods. Biodegradable microspheres coencapsulating Gd-DTPA and human vascular endothelial growth factor (VEGF) were made from poly(1actic-co-glycolic acid) (PLGA). The release of VEGF from the spheres was measured and ...
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Simvastatin is demonstrated to be a potent stimulator for bone formation. However, a high dosage of simvastatin is required to induce bone regeneration in systematic administration, which may result in various side effects. Here we achieved the local administration of simvastatin through fabricating core/shell microspheres. Meanwhile, the addition of platelet derived growth factor (PDGF) encaps...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2013
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2013.08.009